NLRP3i

一种NLRP3炎症体抑制剂；在400µM浓度下对NLRP3的选择性高于NLRP4和AIM2炎症体；抑制LPS诱导的小鼠J774A.1巨噬细胞中IL-1β的释放和ASC寡聚化；在100mg/kg剂量下减少急性心肌梗死小鼠模型中的梗死面积和心肌肌钙蛋白I水平；减少酵母聚糖A诱导的腹膜炎小鼠模型中的腹腔白细胞浸润；在100mg/kg剂量下降低西方饮食诱导的肥胖小鼠模型中的血浆IL-18水平，并减少收缩和舒张功能障碍。An NLRP3 inflammasome inhibitor; selective for NLRP3 over NLRP4 and AIM2 inflammasomes at 400 µM; inhibits LPS-induced IL-1β release and ASC oligomerization in J774A.1 mouse macrophages; reduces infarct size and cardiac levels of troponin I in a mouse model of acute myocardial infarction at 100 mg/kg; reduces peritoneal leukocyte infiltration in a mouse model of zymosan A-induced peritonitis; decreases plasma IL-18 levels and reduces systolic and diastolic dysfunction in a mouse model of Western diet-induced obesity at 100 mg/kg.分子式C16H17ClN2O4S分子量368.8ClC1=CC=C(OC)C(C(NCCC2=CC=C(S(N)(=O)=O)C=C2)=O)=C1