Ganglioside GD1a (bovine) (amm

具有C14:0、C16:0、C18:0、C20:0和C22:0脂肪酰基链的神经节苷脂GD1a分子种类的混合物；一种含唾液酸的鞘糖脂，存在于脑、红细胞、骨髓、睾丸、脾脏和肝脏以及血清脂蛋白中；从肿瘤细胞表面脱落到微环境中，在那里影响肿瘤-宿主细胞相互作用，促进肿瘤细胞增殖、侵袭和转移；与TLR2共定位并在20µM时增强LT-IIb-B5与TLR2的结合；在20µM时增加VEGF诱导的HUVEC增殖；在小鼠的Matrigel™栓塞试验中以20µM/栓塞诱导血管形成；在半乳糖唾液酸贮积症患者的中枢神经系统中积聚。A mixture of ganglioside GD1a molecular species with C14:0, C16:0, C18:0, C20:0, and C22:0 fatty acyl chains; a sialic acid-containing glycosphingolipid that has been found in brain, erythrocytes, bone marrow, testis, spleen, and liver, as well as serum lipoproteins; shed into the microenvironment from the surface of tumor cells, where it influences tumor-host cell interactions to promote tumor cell proliferation, invasion, and metastasis; colocalizes with TLR2 and enhances the binding of LT-IIb-B5 to TLR2 at 20 µM; increases VEGF-induced proliferation of HUVECs at 20 µM; induces vascularization in a Matrigel™ plug assay in mice at 20 µM/plug; accumulates in the CNS of patients with galactosialidosis.分子式C84H146N4O39 • 2NH4 (for stearoyl)分子量1872.2OC[C@H]1O[C@@H](O[C@H]2[C@H](O[C@H]([C@@H]([C@H]2O[C@]3(C([O-])=O)C[C@@H]([C@H]([C@]([C@@H]([C@@H](CO)O)O)(O3)[H])NC(C)=O)O)O)O[C@H]4[C@@H]([C@H]([C@@H](O[C@@H]4CO)OC[C@@H]([C@H](O)/C=C/CCCCCCCCCCCCC)NC([R])=O)O)O)CO)[C@H](NC(C)=O)[C@@H](O[C@@H]5O[C@@H]([C@@H]([C@@H]([C@H]5O)O[C@]6(C([O-])=O)C[C@@H]([C@H]([C@]([C@@H]([C@@H](CO)O)O)(O6)[H])NC(C)=O)O)O)CO)[C@H]1O.[NH4+].[NH4+]