Lyso-Monosialoganglioside GM2

一种缺乏脂肪酰基的神经节苷脂；在无细胞测定中抑制PKC（IC50=50µM）；在患有Sandhoff病或Tay-Sachs病的患者以及Sandhoff病的小鼠模型的死后脑样本中，灰质水平有所增加。A ganglioside lacking the fatty acyl group; inhibits PKC in a cell-free assay (IC50 = 50 µM); gray matter levels are increased in postmortem brain samples from patients with Sandhoff disease or Tay-Sachs disease, as well as a mouse model of Sandhoff disease.分子式C49H86N3O25 • NH4分子量1135.3N[C@H]([C@H](O)/C=C/CCCCCCCCCCCCC)CO[C@@H]1O[C@@H]([C@H]([C@@H]([C@H]1O)O)O[C@H]2[C@@H]([C@H]([C@H]([C@H](O2)CO)O[C@@H]3O[C@@H]([C@@H]([C@@H]([C@H]3NC(C)=O)O)O)CO)O[C@]4(C([O-])=O)C[C@H](O)[C@@H](NC(C)=O)[C@@]([C@@H]([C@H](O)CO)O)([H])O4)O)CO.[NH4+]