Galanin (human) (acetate)

一种神经肽和GAL受体激动剂；抑制表达重组人GAL1受体的HEK293E细胞中福斯高林诱导的cAMP产生（EC50=0.031nM），并刺激表达重组人GAL2受体的CHO细胞中肌醇磷酸积累（EC50=12.3nM）；诱导大鼠离体纵向胃底条带收缩（EC50=13.8nM）；在鞘内注射3、10和30nmol/只的福尔马林试验第二阶段，减少大鼠的舔爪和退缩行为。A neuropeptide and GAL receptor agonist; inhibits forskolin-induced cAMP production in HEK293E cells expressing recombinant human GAL1 receptors (EC50 = 0.031 nM) and stimulates inositol phosphate accumulation in CHO cells expressing recombinant human GAL2 receptors (EC50 = 12.3 nM); induces contractions in isolated rat longitudinal fundus strips (EC50 = 13.8 nM); reduces paw licking and flinching in the second phase of the formalin test in rats at 3, 10, and 30 nmol/animal intrathecally.分子式C139H210N42O43 • XC2H4O2分子量3157.4O=C(N[C@@H](CC1=CNC2=C1C=CC=C2)C(N[C@]([C@H](O)C)([H])C(N[C@H](C(N[C@@H](CC(N)=O)C(N[C@@H](CO)C(N[C@H](C(NCC(N[C@@H](CC3=CC=C(O)C=C3)C(N[C@H](C(N[C@H](C(NCC(N4CCC[C@H]4C(N[C@@H](CC5=CNC=N5)C(N[C@H](C(N[C@@H](C(C)C)C(NCC(N[C@@H](CC(N)=O)C(N[C@@H](CC6=CNC=N6)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CO)C(N[C@H](C(N[C@@H](CO)C(N[C@@H](CC(O)=O)C(N[C@@H](CCCCN[H])C(N[C@@H](CC(N)=O)C(NCC(N[C@H](C(N[C@]([C@H](O)C)([H])C(N[C@@H](CO)C(O)=O)=O)=O)CC(C)C)=O)=O)=O)=O)=O)=O)CC7=CC=CC=C7)=O)=O)=O)=O)=O)=O)=O)C)=O)=O)=O)=O)CC(C)C)=O)CC(C)C)=O)=O)=O)C)=O)=O)=O)CC(C)C)=O)=O)CN[H].CC(O)=O