N-glycolyl-Ganglioside GM3 (am

N-乙醇酰-神经节苷脂GM3的混合物；体外损害树突状细胞的分化和成熟；增加小鼠Lewis肺癌模型中形成的肺肿瘤结节数量；存在于多种癌症中；其水平与NSCLC肿瘤组织中成熟树突状细胞的数量呈负相关；包含主要具有C22:0、C23:0和C24:0脂肪酰基链长的神经节苷脂GM3分子种类。A mixture of of N-glycolyl-ganglioside GM3; impairs differentiation and maturation of dendritic cells in vitro; increases the number of lung tumor nodules formed in a murine Lewis lung carcinoma model; found in a variety of cancers; levels are negatively correlated with the number of mature dendritic cells in NSCLC tumor tissue; contains ganglioside GM3 molecular species with primarily C22:0, C23:0, and C24:0 fatty acyl chain lengths.分子式C64H117N2O22 • NH4 (for tricosanoyl)分子量1284.7O[C@H]1[C@H](O[C@@H]([C@@H]([C@H]2O[C@]3(C([O-])=O)C[C@@H]([C@H]([C@]([C@@H]([C@H](O)CO)O)(O3)[H])NC(CO)=O)O)O)O[C@@H]([C@@H]2O)CO)[C@@H](CO)O[C@@H](OC[C@@H]([C@H](O)/C=C/CCCCCCCCCCCCC)NC([R])=O)[C@@H]1O.[NH4+]