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- 2025年07月21日
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文献和实验Whole Blood Assays for Evaluation of Thromboxane Synthase Inhibition
to generate thromboxane A2 (TXA2 ) in response to an agonist has been assessed, and similar assays figure importantly in the current clinical trials (4 ) of cyclooxygenase-2 (COX-2) inhibitors. Early work by Sun (5 ), carried out with human platelet
Immunochemical Detection of Nitric Oxide Synthase in Human Tissue
To date three distinct isoforms of nitric oxide synthase (NOS) have been identified. Two isoforms are considered to be expressed constitutively—neu-ronal NOS (nNOS; type I NOS) and endothelial NOS (eNOS; type III NOS). The third isoform
Cloning and Expression of Human Inducible Nitric Oxide Synthase
NO synthase (NOS) pathway was first characterized and cloned in murine macrophages (1 –3 ). Activation with lipopolysaccharide (LPS) and interferon-γ (IFN-γ) was uniformly used in these studies to increase inducible (i) NOS expression and improve cloning
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