Folitixorin

叶酸的还原形式和胸苷酸合成酶的辅因子；与胸苷酸合成酶和FdUMP形成三元复合物，抑制胸苷酸合成酶活性和DNA合成；与5-氟尿嘧啶联合使用时分别对LS174或HT-29人结肠癌细胞具有协同或附加的细胞毒作用；与5-氟尿嘧啶联合使用时，以0.6mg/只动物的剂量增加HT-29小鼠异种移植模型的存活率并减少肿瘤生长。A reduced form of folate and cofactor for thymidylate synthetase; forms a ternary complex with thymidylate synthetase and FdUMP that inhibits thymidylate synthetase activity and DNA synthesis; has synergistic or additive cytotoxic effects against LS 174 or HT-29 human colon cancer cells, respectively, when used in combination with 5-fluorouracil; increases survival and reduces tumor growth in an HT-29 mouse xenograft model at 0.6 mg/animal when administered in combination with 5-fluorouracil.分子式C20H23N7O6分子量457.4O=C1C2=C(NC(N)=N1)NCC3N2CN(C4=CC=C(C=C4)C(N[C@H](C(O)=O)CCC(O)=O)=O)C3