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- 2025年07月21日
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依托度酸的II期代谢物；由UGT1A9、UGT1A10和UGT2B7对依托度酸进行葡萄糖醛酸化而形成。A phase II metabolite of etodolac; formed via glucuronidation of etodolac by UGT1A9, UGT1A10, and UGT2B7.分子式C23H29NO9分子量463.5O=C(O[C@@H]([C@@H]([C@H]1O)O)O[C@@H]([C@H]1O)C(O)=O)CC(C2=C3C4=CC=CC(CC)=C4N2)(OCC3)CC
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文献和实验相关实验
In Vitro Assessment of the Reactivity of Acyl Glucuronides
glucuronides are prepared with UDPGA-fortified microsomes and 1-O-β acyl glucuronide is established based on its sensitivity to hydrolysis by β-glucuronidase. The chemical degradation of 1-O-β isomer in 0.1 M phosphate buffer at pH 7.4 is monitored over time
In Vitro Screening Assay of the Reactivity of Acyl Glucuronides
Acyl glucuronides are unstable at physiologic pH and thus can result in free aglycone by hydrolysis and lead to positional isomers by acyl migration. Acylmigrated glucuronide isomers were shown to bind covalently to proteins in vitro
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Etodolac Acyl Glucuronide
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