Brevetoxin 3

一种神经毒素；与Navs的5位点结合，延长平均开放时间并抑制这些通道的失活；诱导CGN释放LDH、L-谷氨酸和L-天冬氨酸（EC50分别为30.9、45.3和50.2nM）；诱发日本稻鱼胚胎的抽搐并致死（LD50=4ng/卵）；在赤潮爆发期间收集的水样中发现。A neurotoxin; binds to site 5 of Navs, prolonging the mean open time and inhibiting inactivation of these channels; induces the release of LDH, L-glutamate, and L-aspartate from CGNs (EC50s = 30.9, 45.3, and 50.2 nM, respectively); induces convulsions in, and is lethal to (LD50 = 4 ng/egg), Japanese rice fish embryos; has been found in water samples collected during red tide blooms.分子式C50H72O14分子量897.1C[C@@]12[C@](C[C@@]3([H])[C@](O2)(CC[C@@]4([H])[C@]([C@@H](C[C@@]5([H])[C@](C[C@]6([C@](C[C@@]7([H])[C@](C(C)=CC(O7)=O)([H])O6)([H])O5)C)([H])O4)C)([H])O3)C)([H])O[C@@]8([C@@](O[C@]9([H])[C@@](O[C@]%10([H])[C@@](O[C@@]%11([C@@](O[C@@H](C[C@@H]%11O)CC(CO)=C)([H])C%10)C)([H])C9)([H])C=CC8)([H])C1)C