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文献和实验Random Mutagenesis of Peptide Aptamers as an Optimization Strategy for Inhibitor Screening
Accumulating work over the past decade has shown that peptide aptamer screening represents a valid strategy for inhibitor identification that can be applied to a variety of different targets. Because of the screening method in cells
Inhibitor Screening of Proprotein Convertases Using Positional Scanning Libraries
can be accomplished by screening synthetic combinatorial libraries containing thousands of small molecules to millions of peptides. In this chapter, the screening of positional scanning libraries is described for the identification of PC1/3 and PC2 inhibitors.
DNA-Directed Assembly Microarray for Protein and Small Molecule Inhibitor Screening
A robust high-throughput and high-fidelity screening platform for identifying and validating potential target molecules is the key for drug development. During the past decade, microarray platforms have demonstrated enormous potential
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