113-O12B

一种可电离的阳离子脂质；已用于生成用于递送mRNA的LNP；皮下注射含有113-O12B并封装mRNA报告基因的LNP会特异性地聚集在小鼠淋巴结中；含有113-O12B并封装编码卵清蛋白的mRNA的LNP可减少肿瘤生长，并增加表达卵清蛋白的B16/F10鼠黑色素瘤模型中的肿瘤CD8+T细胞、M1样巨噬细胞和活化树突状细胞的数量。An ionizable cationic lipidoid; has been used in the generation of LNPs for the delivery of mRNA; subcutaneous administration of LNPs containing 113-O12B and encapsulating an mRNA reporter accumulate specifically in mouse lymph nodes; LNPs containing 113-O12B and encapsulating mRNA encoding ovalbumin reduce tumor growth and increase the number of tumoral CD8+ T cells, M1-like macrophages, and activated dendritic cells in an ovalbumin-expressing B16/F10 murine melanoma model.分子式C57H111N3O8S8分子量1223O=C(CCN(CCN(CCN(CCC(OCCSSCCCCCCCC)=O)CCC(OCCSSCCCCCCCC)=O)C)CCC(OCCSSCCCCCCCC)=O)OCCSSCCCCCCCC