OF-02

一种可离子化的阳离子氨基脂质；已与其他脂质结合用于形成LNP，以递送mRNA；含有OF-02的LNP在小鼠静脉内给药后定位到肝脏；静脉内给药含有OF-02并封装人类EPO mRNA的LNP可提高小鼠血清EPO水平。An ionizable cationic amino lipid; has been used in combination with other lipids in the formation of LNPs for the delivery of mRNA; LNPs containing OF-02 localize to the liver after intravenous administration in mice; intravenous administration of LNPs containing OF-02 and encapsulating human EPO mRNA increases serum EPO levels in mice.分子式C84H152N4O6分子量1314.1CCCCC/C=C\C/C=C\CCCCCCC(O)CN(CC(O)CCCCCC/C=C\C/C=C\CCCCC)CCCCC1C(NC(C(N1)=O)CCCCN(CC(O)CCCCCC/C=C\C/C=C\CCCCC)CC(O)CCCCCC/C=C\C/C=C\CCCCC)=O