Caveolin-1 (82-101) amide (hum

Caveolin-1的合成肽片段；在0.8µmol/kg的浓度下，可降低老年小鼠心脏、肾脏和脑中因衰老引起的微血管渗漏和纤维化的增加，以及磷酸化与非磷酸化的PDGFR和Pyk2的比率；增加左心室射血分数和缩短分数，并减少老年小鼠因衰老引起的IVRT和心脏肥大。A synthetic peptide fragment of caveolin-1; reduces aging-induced increases in microvascular leakage and fibrosis, as well as the ratio of phosphorylated-to-unphosphorylated PDGFR and Pyk2, in aged mouse heart, kidney, and brain at 0.8 µmol/kg; increases left ventricular ejection fraction and fractional shortening and reduces aging-induced IVRT and cardiac hypertrophy in aged mice.分子式C124H170N28O29 • XCF3COOH分子量2516.9OC(C(F)(F)F)=O.[H]N[C@H](C(NCC(N[C@]([C@H](CC)C)([H])C(N[C@H](C(N[C@@H](CCCCN)C(N[C@H](C(N[C@@H](CO)C(N[C@H](C(N[C@]([C@@H](C)O)([H])C(N[C@]([C@@H](C)O)([H])C(N[C@H](C(N[C@]([C@@H](C)O)([H])C(N[C@@H](C(C)C)C(N[C@]([C@@H](C)O)([H])C(N[C@@H](CCCCN)C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@@H](CCCNC(N)=N)C(N)=O)=O)CC1=CC=C(O)C=C1)=O)CC2=CC=CC=C2)=O)CC3=CNC4=C3C=CC=C4)=O)CC5=CC=C(O)C=C5)=O)=O)=O)=O)=O)CC6=CC=CC=C6)=O)=O)=O)CC7=CC=CC=C7)=O)=O)C)=O)=O)CC8=CNC9=C8C=CC=C9)=O)=O)=O)CC(O)=O