Entecavir

一种抗病毒核苷类似物和HBV逆转录酶抑制剂（IC50=0.5nM）；降低感染HBV的HepG2 2.2.15细胞培养上清液中的病毒DNA（EC50=3.75nM）；以1mg/kg的剂量降低HBV感染鸭模型中血清和肝脏中的病毒DNA水平。An antiviral nucleoside analog and inhibitor of HBV reverse transcriptase (IC50 = 0.5 nM); reduces virion DNA in the culture supernatant of HepG2 2.2.15 cells infected with HBV (EC50 = 3.75 nM); reduces serum and hepatic levels of viral DNA in a duckling model of HBV infection at 1 mg/kg.分子式C12H15N5O3分子量277.3O=C(N=C(N1)N)C2=C1N([C@@]3([H])C[C@H](O)[C@@H](CO)C3=C)C=N2