Gingerenone A

一种具有多种生物活性的二芳基庚烷类化合物和多酚；抑制酪氨酸酶（蘑菇酶的IC50=9.4µM）；在无细胞测定中清除DPPH自由基（IC50=12.6µM）；在5和10µM时抑制JAK2和p70S6K1；在20µM时选择性地降低电离辐射诱导的衰老WI38成纤维细胞相对于增殖成纤维细胞的活力；在50mg/kg时防止体重增加但不影响高脂饮食诱导的肥胖小鼠模型的热量摄入；在5和20mg/kg时降低HCT116结肠癌小鼠异种移植模型中的肿瘤重量。A diarylheptanoid and polyphenol with diverse biological activities; inhibits tyrosinase (IC50 = 9.4 µM for the mushroom enzyme); scavenges DPPH radicals in a cell-free assay (IC50 = 12.6 µM); inhibits JAK2 and p70S6K1 at 5 and 10 µM; selectively decreases the viability of ionizing radiation-induced senescent WI38 fibroblasts over proliferating fibroblasts at 20 µM; prevents increases in body weight but does not affect caloric intake in a mouse model of high-fat diet-induced obesity at 50 mg/kg; decreases tumor weight in an HCT116 colon cancer mouse xenograft model at 5 and 20 mg/kg.分子式C21H24O5分子量356.4COC(C=C1CC/C=C/C(CCC2=CC(OC)=C(C=C2)O)=O)=C(C=C1)O