E3 Ligase Ligand 2

沙利度胺的活性代谢物和PROTAC合成中间体；浓度为30µM时可降低THP-1细胞中TPA诱导的TNF-α生成；浓度为333µM时可完全抑制HUVEC增殖；浓度为100µg/胚胎时，在子宫内CAM测定中可抑制VEGF和FGF2诱导的血管生成14%。An active metabolite of thalidomide and a PROTAC synthetic intermediate; decreases production of TNF-α induced by TPA in THP-1 cells at 30 µM; completely inhibits the proliferation HUVECs at 333 µM; inhibits VEGF- and FGF2-induced angiogenesis by 14% in a CAM assay in utero at 100 µg/embryo.分子式C13H10N2O5分子量274.2O=C1C2=C(C(N1C3C(NC(CC3)=O)=O)=O)C(O)=CC=C2