WRN 多克隆抗体

免疫组织化学（IHC）已验证样本:Human gastric cancer,Human breast cancer

IHC 1:30-1:150, ELISA 1:5000-1:10000

Polyclonal

IgG

Synthetic peptide of human WRN

WRN

DKFZp686C2056;DNA helicase;DNA helicase; RecQ like type 3;Exonuclease WRN;HGNC 12791;OTTHUMP00000225301;RecQ protein-like 2;RecQ-like type 3;RecQ3;RECQL2;RECQL3;Werner syndrome ATP-dependent helicase;Werner syndrome helicase;Werner syndrome protein;Werner syndrome; RecQ helicase like;WRN;WRN抗体

Q14191

Nucleus>nucleolus. Nucleus.

0.8 mg/mL

在-20℃下储存有效期为12个月。 避免冻融循环。

PBS with 0.05% NaN3 and 40% Glycerol,pH7.4

Antigen affinity purification

Cancer; Epigenetics and Nuclear Signaling

Unconjugated

This gene encodes a member of the RecQ subfamily and the DEAH (Asp-Glu-Ala-His) subfamily of DNA and RNA helicases. DNA helicases are involved in many aspects of DNA metabolism, including transcription, replication, recombination, and repair. This protein contains a nuclear localization signal in the C-terminus and shows a predominant nucleolar localization. It possesses an intrinsic 3' to 5' DNA helicase activity, and is also a 3' to 5' exonuclease. Based on interactions between this protein and Ku70/80 heterodimer in DNA end processing, this protein may be involved in the repair of double strand DNA breaks. Defects in this gene are the cause of Werner syndrome, an autosomal recessive disorder characterized by premature aging.