NOTCH4 多克隆抗体

Western Blot（WB）已验证样本:Human kidney

WB 1:800-1:2000, ELISA 1:5000-1:10000

Polyclonal

IgG

Synthetic peptide of human NOTCH4

NOTCH4

FLJ16302;hNotch 4;hNotch4;INT3;Neurogenic locus notch homolog protein 4;NOTC4;Notch 4;Notch 4 intracellular domain;Notch homolog 4;NOTCH3;Notch4;NOTCH4 protein抗体

Q99466

210 kDa

Refer to figures

Cell membrane and Nucleus. Following proteolytical processing NICD is translocated to the nucleus.

0.9 mg/mL

在-20℃下储存有效期为12个月。 避免冻融循环。

PBS with 0.05% NaN3 and 40% Glycerol,pH7.4

Antigen affinity purification

Cancer; Cardiovascular; Epigenetics and Nuclear Signaling; Stem Cells

Unconjugated

This gene encodes a member of the Notch family. Members of this Type 1 transmembrane protein family share structural characteristics including an extracellular domain consisting of multiple epidermal growth factor-like (EGF) repeats, and an intracellular domain consisting of multiple, different domain types. Notch family members play a role in a variety of developmental processes by controlling cell fate decisions. The Notch signaling network is an evolutionarily conserved intercellular signaling pathway which regulates interactions between physically adjacent cells. In Drosophilia, notch interaction with its cell-bound ligands (delta, serrate) establishes an intercellular signaling pathway that plays a key role in development. Homologues of the notch-ligands have also been identified in human, but precise interactions between these ligands and the human notch homologues remain to be determined. This protein is cleaved in the trans-Golgi network, and presented on the cell surface as a heterodimer. This protein functions as a receptor for membrane bound ligands, and may play a role in vascular, renal and hepatic development. This gene may be associated with susceptibility to schizophrenia in a small portion of cases. An alternative splice variant has been described but its biological nature has not been determined.