ZD 7155 (hydrochloride)

AT1受体拮抗剂(IC50=3.3nM)；抑制清醒正常血压大鼠中血管紧张素II诱发的升压反应；以1.082µmol/kg的剂量降低清醒自发性高血压大鼠的平均动脉压；以10mg/kg的剂量（饮用水中）改善链脲佐菌素诱发的糖尿病性神经病变大鼠模型中坐骨神经的运动神经传导速度；以10mg/kg的剂量（LPS诱发的急性肺损伤小鼠模型中）降低病情严重程度以及NF-κB和AP-1的活化。An AT1 receptor antagonist (IC50 = 3.3 nM); inhibits angiotensin II-induced pressor responses in conscious normotensive rats; decreases mean arterial pressure in conscious spontaneously hypertensive rats at 1.082 µmol/kg; improves motor nerve conduction velocity in the sciatic nerve in a rat model of streptozotocin-induced diabetic neuropathy at 10 mg/kg in the drinking water; decreases disease severity and NF-κB and AP-1 activation in a mouse model of LPS-induced acute lung injury at 10 mg/kg.分子式C26H26N6O • HCl分子量475O=C1N(CC2=CC=C(C3=C(C4=NN=NN4)C=CC=C3)C=C2)C5=CC(CC)=NC(CC)=C5CC1.Cl