Kinetin Riboside

一种抗癌核苷；诱导HepG2细胞中ROS的产生、细胞ATP的耗竭和细胞凋亡；降低细胞周期蛋白D1和细胞周期蛋白D2的水平，并在10µM浓度下诱导患者来源的多发性骨髓瘤细胞在G1期发生细胞周期停滞和细胞凋亡；降低OCI-My5和RPMI-8226骨髓瘤小鼠异种移植模型中的肿瘤生长。An anticancer nucleoside; induces ROS production, cellular ATP depletion, and apoptosis in HepG2 cells; reduces cyclin D1 and cyclin D2 levels, as well as induces cell cycle arrest at the G1 phase and apoptosis in patient-derived multiple myeloma cells at 10 µM; reduces tumor growth in OCI-My5 and RPMI-8226 myeloma mouse xenograft models.分子式C15H17N5O5分子量347.3O[C@H]1[C@](O[C@@H]([C@H]1O)CO)([H])N2C3=NC=NC(NCC4=CC=CO4)=C3N=C2