L-Pyroglutamic Acid

L-谷氨酸的环化形式；10µM时L-焦谷氨酸-Aβ(3-42)的聚集速度比Aβ(3-42)和Aβ42更快；昆虫AKH的成分；在500mg/kg剂量下，增加大鼠在Vogel惩罚性饮酒任务中接受电击的次数，表明具有抗焦虑样活性；终末期肾病患者的血浆水平升高；在阿尔茨海默病患者的脑组织中发现了含有pGlu的Aβ斑块；已用于合成FAP抑制剂。A cyclized form of L-glutamic acid; L-pyroglutamic acid-Aβ (3-42) aggregates at a higher rate than Aβ (3-42) and Aβ42 at 10 µM; a component of AKH in insects; increases the number of received shocks in the Vogel punished drinking task, indicating anxiolytic-like activity, in rats at 500 mg/kg; plasma levels are increased in patients with end-stage renal disease; pGlu-containing Aβ plaques have been found in brain tissue from patients with Alzheimer's disease; has been used in the synthesis of FAP inhibitors.分子式C5H7NO3分子量129.1O=C1CC[C@@H](C(O)=O)N1