Pt(II)-NHC Complex 2C

免疫原性癌细胞死亡的诱导剂；选择性抑制HT-29、MCF-7、A2780、A549、HepG2和Hepa1-6癌细胞的增殖（IC50分别为2.78、0.71、0.99、1.77、0.33和0.36µM），而非癌性L-02肝细胞（IC50=3.02µM）；诱导Hepa1-6细胞中ICD相关DAMP的释放；在植入前Hepa1-6细胞中5µM浓度的ICD反应小鼠抗肿瘤疫苗接种模型中，可降低肿瘤生长。An inducer of immunogenic cancer cell death; selectively inhibits proliferation of HT-29, MCF-7, A2780, A549, HepG2, and Hepa 1-6 cancer cells (IC50s = 2.78, 0.71, 0.99, 1.77, 0.33, and 0.36 µM, respectively) over non-cancerous L-02 liver cells (IC50 = 3.02 µM); induces the release of ICD-associated DAMPs in Hepa 1-6 cells; reduces tumor growth in a mouse antitumor vaccination model of the ICD response in mice at 5 µM in Hepa 1-6 cells prior to implantation.分子式C24H23F2I2N3Pt分子量840.3I[Pt](I)([N]1=CC=CC=C1)=C(N(C(C(C=C2)=CC=C2F)=C3C(C=C4)=CC=C4F)CC)N3CC