Rhodojaponin III

一种具有杀虫和镇痛活性的二萜类化合物；浓度为75和150ppm时，可减少马铃薯植株上的科罗拉多马铃薯甲虫(L.decemlineata)幼虫的化蛹和数量，并减少对马铃薯植株的损害；在小鼠化学性、炎症性和神经性疼痛模型中具有抗痛作用，包括乙酸扭体试验(ID50=0.0469mg/kg)；在0.04和0.08mg/kg时，可提高糖尿病周围神经性疼痛小鼠模型对机械刺激的爪缩回阈值；对小鼠有毒性(LD50=0.271mg/kg)。A diterpenoid with insecticidal and antinociceptive activities; reduces pupation and the number of Colorado potato beetle (L. decemlineata) larvae on, and damage to, potato plants at 75 and 150 ppm; has antinociceptive effects in mouse models of chemical, inflammatory, and neuropathic pain, including the acetic acid writhing test (ID50 = 0.0469 mg/kg); increases the paw withdrawal threshold for mechanical stimuli in a mouse model of diabetic peripheral neuropathic pain at 0.04 and 0.08 mg/kg; toxic to mice (LD50 = 0.271 mg/kg).分子式C20H32O6分子量368.5O[C@H]1[C@@](C[C@H]2O)(C[C@]3(O)C)[C@](CC[C@]13[H])([H])[C@@](O)([C@@]([C@@](O4)([H])[C@@]4([H])C(C)5C)([H])[C@]25O)C