Flavokawain A

一种具有多种生物活性的查耳酮；激活Nrf2和Hsf1（报告分析中的EC50s分别为14.1和7.9µM），提高GSH水平，并保护HepG2细胞免受过氧化氢诱导的细胞毒性；在10和20µM时抑制RAW 264.7巨噬细胞中LPS诱导的iNOS、COX-2、NO和PGE2水平的增加；在12.5µg/ml时诱导T24膀胱癌细胞凋亡；在50mg/kg时降低EJ膀胱癌小鼠异种移植模型中的肿瘤生长。A chalcone with diverse biological activities; activates Nrf2 and Hsf1 (EC50s = 14.1 and 7.9 µM, respectively, in reporter assays), increases GSH levels, and protects against hydrogen peroxide-induced cytotoxicity in HepG2 cells; inhibits LPS-induced increases in iNOS, COX-2, NO, and PGE2 levels in RAW 264.7 macrophages at 10 and 20 µM; induces apoptosis in T24 bladder cancer cells at 12.5 µg/ml; reduces tumor growth in an EJ bladder cancer mouse xenograft model at 50 mg/kg.分子式C18H18O5分子量314.3COC1=C(C(O)=CC(OC)=C1)C(/C=C/C2=CC=C(C=C2)OC)=O