Tubercidin

具有多种生物活性的核苷类似物；对粪链球菌有效（IC50=0.02µM）；对P388和A549细胞有细胞毒性（IC50s分别为0.008和0.019µg/ml）；可降低SARS-CoV-2对Calu-3细胞的感染（EC50=0.05µM），但对A549-ACE2和Vero细胞有毒性；与NBMPR-P联合使用5mg/kg可提高血吸虫病小鼠模型的存活率，但单独以相同剂量给药四天有毒性并导致死亡。A nucleoside analog with diverse biological activities; active against S. faecalis (IC50 = 0.02 µM); cytotoxic to P388 and A549 cells (IC50s = 0.008 and 0.019 µg/ml, respectively); reduces infection of Calu-3 cells by SARS-CoV-2 (EC50 = 0.05 µM) but is toxic to A549-ACE2 and Vero cells; increases survival in a mouse model of schistosomiasis when used at 5 mg/kg in combination with NBMPR-P but is toxic and induces mortality when administered alone at the same dose for four days.分子式C11H14N4O4分子量266.3O[C@H]1[C@](O[C@@H]([C@H]1O)CO)([H])N2C3=NC=NC(N)=C3C=C2