Isomeranzin

一种具有抗氧化和抗炎活性的香豆素；抑制细胞松弛素B和fMLP刺激的分离人类中性粒细胞中的超氧化物阴离子生成和弹性蛋白酶释放（IC50s分别为3.89和4.33µM）；在30µM时抑制RAW 264.7巨噬细胞中LPS诱导的NO释放；在30mg/kg时提高LPS诱导的脓毒症休克小鼠模型的存活率，降低DSS诱导的结肠炎小鼠模型的病情严重程度。A coumarin with antioxidant and anti-inflammatory activities; inhibits superoxide anion generation in, and elastase release from, cytochalasin B- and fMLP-stimulated isolated human neutrophils (IC50s = 3.89 and 4.33 µM, respectively); inhibits LPS-induced NO release in RAW 264.7 macrophages at 30 µM; improves survival in a mouse model of LPS-induced septic shock and decreases disease severity in a mouse model of DSS-induced colitis at 30 mg/kg.分子式C15H16O4分子量260.3O=C1OC2=C(C=CC(OC)=C2CC(C(C)C)=O)C=C1