Mitochonic Acid 5

线粒体功能障碍的抑制剂；3µM时可增加Hep3B细胞中的细胞内ATP水平；5µM时可挽救LPS诱导的细胞凋亡并降低BV-2小胶质细胞中的线粒体膜电位；以电子传递链非依赖的方式保护患有各种线粒体疾病的患者分离的成纤维细胞免受BSO诱导的细胞活力下降（EC50s=2.3-5.1µM）；50mg/kg时可降低小鼠双侧腹膜后肾缺血再灌注损伤模型中的血浆肌酐水平并减少急性肾小管坏死。An inhibitor of mitochondrial dysfunction; increases intracellular ATP levels in Hep3B cells at a 3 µM; rescues LPS-induced apoptosis and decreases in the mitochondrial membrane potential in BV-2 microglial cells at 5 µM; protects against BSO-induced decreases in cell viability in fibroblasts isolated from patients with various mitochondrial diseases (EC50s = 2.3-5.1 µM) in an electron transport chain-independent manner; reduces plasma levels of creatinine and decreases acute renal tubular necrosis in a mouse model of bilateral retroperitoneal renal ischemia-reperfusion injury at 50 mg/kg.分子式C18H13F2NO3分子量329.3O=C(C(CC(C1=CC=C(C=C1F)F)=O)C2=CNC3=C2C=CC=C3)O