Indium (III) thiosemicarbazone

一种抗癌剂；对A549、MCF-7乳腺癌、MCF-7/DDP顺铂耐药乳腺癌和Hl7702肝癌细胞具有细胞毒性（IC50s分别为2.41、1.97、2.11µM和8.95µM）；降低MCF-7/DDP细胞中的PI3K、Akt、mTOR、P-gp和GSH水平；在2.5µmol/kg浓度下减少MCF-7/DDP小鼠异种移植模型中的肿瘤重量和体积；含有该物质的脂质体可诱导MCF-7/DDP细胞凋亡和促死亡自噬，并减少MCF-7/DDP小鼠异种移植模型中的肿瘤体积和重量。An anticancer agent; cytotoxic to A549, MCF-7 breast, MCF-7/DDP cisplatin-resistant breast, and Hl 7702 liver cancer cells (IC50s = 2.41, 1.97, 2.11 µM, and 8.95 µM, respectively); decreases PI3K, Akt, mTOR, P-gp, and GSH levels in MCF-7/DDP cells; reduces tumor weight and volume in an MCF-7/DDP mouse xenograft model at 2.5 µmol/kg; liposomes containing it induce apoptosis and pro-death autophagy in MCF-7/DDP cells, as well as reduce tumor volume and weight in an MCF-7/DDP mouse xenograft model.分子式C10H15Cl2InN4OS分子量425[Cl-][In+3]12([O-]C)([S]=C([N](C)C)[NH][N]1=CC3=CC=CC=[N]32)[Cl-]