Lupenone

一种三萜类化合物；抑制HIV-1逆转录酶（IC50=2.1μM）；对抗恶性疟原虫W2和D6株有效（IC50分别为208.1和394.7ng/ml）；诱导黑色素生成（EC50=0.35µM），并抑制B162F2细胞体外生长（IC50=25.4µM）；局部应用可减轻小鼠TPA诱发的耳部水肿（1mg/耳）；抑制小鼠乙酸诱发的翻滚（100mg/kg）。A triterpenoid; inhibits HIV-1 reverse transcriptase (IC50 = 2.1 μM); active against the W2 and D6 strains of P. falciparum (IC50s = 208.1 and 394.7 ng/ml, respectively); induces melanogenesis in (EC50 = 0.35 µM), and inhibits the growth of, B16 2F2 cells in vitro (IC50 = 25.4 µM); topical application reduces TPA-induced ear edema in mice at 1 mg/ear; inhibits acetic acid-induced writhing in mice at 100 mg/kg.分子式C30H48O分子量424.7C[C@]12[C@@](CC[C@@]3([H])[C@]2(CC[C@]4([H])[C@@]3(CCC(C4(C)C)=O)C)C)([H])[C@]5([H])[C@@](CC1)(CC[C@H]5C(C)=C)C