L6H21

MD-2和TLR4相互作用的抑制剂；与MD-2结合（无细胞测定中Kd=33.3µM）；抑制LPS刺激的ECV304细胞中MD-2和TLR4之间的蛋白质-蛋白质相互作用；在10µM时降低LPS刺激的HCT116细胞的迁移；抑制LPS诱导的小鼠原代巨噬细胞中TNF-α和IL-6产生的增加（IC50s分别为6.17和7.72µM）；提高LPS诱导的脓毒症小鼠模型的存活率；提高高脂饮食大鼠心脏中GPX4的水平并降低心脏线粒体ROS。An inhibitor of the MD-2 and TLR4 interaction; binds to MD-2 (Kd = 33.3 µM in a cell-free assay); inhibits the protein-protein interaction between MD-2 and TLR4 in LPS-stimulated ECV304 cells; decreases the migration of LPS-stimulated HCT116 cells at 10 µM; inhibits LPS-induced increases in the production of TNF-α and IL-6 in mouse primary macrophages (IC50s = 6.17 and 7.72 µM, respectively); increases survival in a mouse model of LPS-induced sepsis; increases cardiac levels of GPX4 and decreases cardiac mitochondrial ROS in rats fed a high-fat diet.分子式C18H18O4分子量298.3COC1=C(C=CC=C1OC)/C=C/C(C2=CC=C(C=C2)OC)=O