2-Chloroadenosine 5-triphospha

腺嘌呤核苷酸和ATP类似物；嘌呤能P2Y1受体拮抗剂（在表达人类受体的Jurkat细胞中Ki=2.3µM）；嘌呤能P2X受体激动剂，在表达人类膀胱平滑肌的HEK293细胞或大鼠PC12形式的受体中诱导内向电流（EC50s分别为0.5和2.5µM）；以浓度依赖性方式诱导预收缩的豚鼠分离盲肠带松弛；已用于研究环核苷酸依赖性蛋白激酶的底物特异性。An adenine nucleotide and ATP analog; antagonist of the purinergic P2Y1 receptor (Ki = 2.3 µM in Jurkat cells expressing the human receptor); an agonist of purinergic P2X receptors, inducing inward currents in HEK293 cells expressing the human bladder smooth muscle or rat PC12 forms of the receptor (EC50s = 0.5 and 2.5 µM, respectively); induces relaxation of precontracted isolated guinea pig taenia caeci strips in a concentration-dependent manner; has been used to study the substrate specificity of cyclic nucleotide-dependent protein kinases.分子式C10H11ClN5O13P3 • 4Na分子量629.6O[C@H]1[C@](O[C@@H]([C@H]1O)COP(OP(OP([O-])([O-])=O)([O-])=O)([O-])=O)([H])N2C3=NC(Cl)=NC(N)=C3N=C2.[Na+].[Na+].[Na+].[Na+]