Soticlestat

胆固醇24-羟化酶/CYP46A1抑制剂(IC50=0.0074µM)；对胆固醇24-羟化酶具有选择性，优于CYP2C8、-2C9、-2D6、-3A4、-1A2和2C19（IC50s分别为62、19、>100、66、>100和14µM）；在饮食中添加0.02%可降低Scn1a+/-小鼠高温诱发的Dravet综合征模型中的癫痫发作频率和严重程度，并提高生存率。A cholesterol 24-hydroxylase/CYP46A1 inhibitor (IC50 = 0.0074 µM); selective for cholesterol 24-hydroxylase over CYP2C8, -2C9, -2D6, -3A4, -1A2, and 2C19 (IC50s = 62, 19, >100, 66, >100, and 14 µM, respectively); reduces seizure frequency and severity and improves survival in a model of Dravet syndrome induced by hyperthermia in Scn1a+/- mice at 0.02% in the diet.分子式C23H23N3O2分子量373.4O=C(N1CCC(CC2=CC=CC=C2)(CC1)O)C3=C(C4=CC=NC=C4)N=CC=C3