IMMA

CB2受体反向激动剂（重组人CB2的Ki=435nM）；对CB2受体的选择性优于CB1受体（Ki=>20µM）；降低肌醇磷酸的基础产生，并增加表达0.001-1µM人CB2受体的HEK293细胞中福斯高林诱导的cAMP积累；抑制J774巨噬细胞中LPS诱导的NO和PGE2产生。A CB2 receptor inverse agonist (Ki = 435 nM for recombinant human CB2); selective for CB2 over CB1 receptors (Ki = >20 µM); reduces basal production of inositol phosphate and increases forskolin-induced accumulation of cAMP in HEK293 cells expressing human CB2 receptors from 0.001-1 µM; inhibits LPS-induced NO and PGE2 production in J774 macrophages.分子式C23H23ClN2O4分子量426.9CC1=C(C(C=C(OC)C=C2)=C2N1C(C3=CC=C(Cl)C=C3)=O)CC(N4CCOCC4)=O