Cyclo(RGDyK) (trifluoroacetate

αVβ3整合素的环肽配体(IC50=37.5nM)；已与各种放射性标记物或荧光探针结合，用于可视化αVβ3介导的新血管生成或对活体小鼠中表达αVβ3的肿瘤进行光学成像；还已与SN38结合形成靶向αVβ3过表达细胞的前药并诱导KB细胞的细胞毒性。A cyclic peptide ligand of αVβ3 integrin (IC50 = 37.5 nM); has been conjugated to various radiolabels or fluorescent probes for the visualization of αVβ3-mediated neoangiogenesis or optical imaging of αVβ3-expressing tumors in live mice; has also been conjugated to SN38 to form a prodrug that targets αVβ3-overexpressing cells and induces cytotoxicity in KB cells.分子式C27H41N9O8 • XCF3COOH分子量619.7O=C(N[C@H](C(N[C@H](C(NCC(N[C@H](C(N1)=O)CC(O)=O)=O)=O)CCCNC(N)=N)=O)CCCCN)[C@H]1CC2=CC=C(C=C2)O.OC(C(F)(F)F)=O