Atractylodin

具有多种生物活性的聚乙烯炔烃；抑制NAAA（对于人类酶，IC50=2.81µM）；在10µM时增加LPS刺激的BV-2细胞中棕榈酰乙醇酰胺和油酰乙醇酰胺的水平；对CL-6和HuCC-T1细胞有细胞毒性（IC50s分别为41.66和38.78µM）；在10mg/kg时增加小鼠的胃排空率；在40和80mg/kg时减少LPS诱发的急性肺损伤小鼠模型中的肺水肿。A polyethylene alkyne with diverse biological activities; inhibits NAAA (IC50 = 2.81 µM for the human enzyme); increases levels of palmitoyl ethanolamide and oleoyl ethanolamide in LPS-stimulated BV-2 cells at 10 µM; cytotoxic to CL-6 and HuCC-T1 cells (IC50s = 41.66 and 38.78 µM, respectively); increases the gastric emptying rate in mice at 10 mg/kg; decreases pulmonary edema in a mouse model of LPS-induced acute lung injury at 40 and 80 mg/kg.分子式C13H10O分子量182.2C/C=C/C#CC#C/C=C/C1=CC=CO1