Prim-O-Glucosylcimifugin

一种具有多种生物活性的色原酮；浓度为10µM时可抑制EGF刺激的MCF-7细胞增殖；浓度为15、50和100µg/ml时可减少LPS诱导的RAW 264.7巨噬细胞中NO、TNF-α、IL-6和IL-1β的产生增加；浓度为2.5-10mg/kg时可减轻LPS诱导的急性肺损伤小鼠模型中的肺水肿；可抑制福尔马林诱导的大鼠强直性疼痛（ED50=1.6mg/只动物）。A chromone with diverse biological activities; inhibits proliferation of EGF-stimulated MCF-7 cells at 10 µM; reduces LPS-induced increases in the production of NO, TNF-α, IL-6, and IL-1β in RAW 264.7 macrophages at 15, 50, and 100 µg/ml; decreases pulmonary edema in a mouse model of LPS-induced acute lung injury at 2.5-10 mg/kg; inhibits formalin-induced tonic pain in rats (ED50 = 1.6 mg/animal).分子式C22H28O11分子量468.5COC1=C(C[C@@H](C(C)(O)C)O2)C2=CC(OC(CO[C@@H]3O[C@@H]([C@H]([C@@H](O)[C@H]3C)O)CO)=C4)=C1C4=O