Chikusetsusaponin IVa

一种具有多种生物活性的齐墩果烷型三萜类化合物；抑制HL-60和HCT116细胞的生长（IC50s分别为76.23和78.11µM）；在50-200µg/ml浓度下降低PMA分化的THP-1巨噬细胞中LPS诱导的iNOS、COX-2、IL-1β、IL-6和TNF-α水平的增加；在45-180mg/kg浓度下降低STZ和高脂饮食诱发的2型糖尿病大鼠模型中的血糖、甘油三酯和LDL胆固醇水平，并增加HDL胆固醇水平。An oleanane-type triterpenoid with diverse biological activities; inhibits the growth of HL-60 and HCT116 cells (IC50s = 76.23 and 78.11 µM, respectively); reduces LPS-induced increases in iNOS, COX-2, IL-1β, IL-6, and TNF-α levels in PMA-differentiated THP-1 macrophages at 50-200 µg/ml; decreases plasma glucose, triglyceride, and LDL-cholesterol, and increases HDL-cholesterol, levels in a rat model of STZ- and high-fat diet-induced type 2 diabetes at 45-180 mg/kg.分子式C42H66O14分子量795OC[C@H]([C@H]([C@@H]([C@H]1O)O)O)O[C@H]1OC([C@]23[C@](CC(C)(CC3)C)([H])C4=CC[C@@]([C@@]5([C@@](C(C)([C@H](CC5)O[C@@H]6O[C@@H]([C@H]([C@@H]([C@H]6O)O)O)C(O)=O)C)([H])CC7)C)([H])[C@]7(C)[C@@]4(CC2)C)=O