Fraxinellone

一种类柠檬酸降解物；以5、10或20mg/ml的浓度施用于新鲜小麦叶上时，可对粘虫幼虫产生拒食作用并抑制其发育；可降低LPS诱导的NF-κB亚基p65核易位，并抑制LPS诱导的RAW 264.7细胞中NO和PGE2的产生；以30或100mg/kg的浓度施用于A549小鼠异种移植模型中时，可降低肿瘤生长。A liminoid degradant; has antifeedant activity against, and inhibits development of, armyworm larvae when applied to fresh wheat leaves at 5, 10, or 20 mg/ml; reduces LPS-induced nuclear translocation of the NF-κB subunit p65, as well as inhibits LPS-induced production of NO and PGE2 in RAW 264.7 cells; reduces tumor growth in an A549 mouse xenograft model at 30 or 100 mg/kg.分子式C14H16O3分子量232.3CC1=C2C(=O)O[C@@H](c3cocc3)[C@]2(C)CCC1