Engeletin

一种黄酮类糖苷；在无细胞测定中清除ABTS自由基（IC50=18.13µg/ml）；在2µg/ml浓度下诱导MCF-7和MDA-MB-231人类乳腺癌细胞凋亡；抑制分离的大鼠软骨细胞中LPS诱导的IL-1β、IL-6和NO的产生，并减少手术诱发的骨关节炎大鼠模型中软骨侵蚀和发炎关节中的蛋白多糖损失。A flavonoid glycoside; scavenges ABTS radicals in a cell-free assay (IC50 = 18.13 µg/ml); induces apoptosis in MCF-7 and MDA-MB-231 human breast cancer cells at 2 µg/ml; inhibits LPS-induced production of IL-1β, IL-6, and NO in isolated rat chondrocytes, as well as reduces cartilage erosion and the loss of proteoglycan in the inflamed joints in a rat model of surgically induced osteoarthritis.分子式C21H22O10分子量434.4O=C([C@@H]([C@](C1=CC=C(C=C1)O)([H])OC2=CC(O)=C3)O[C@H]4[C@@H]([C@@H]([C@H]([C@@H](O4)C)O)O)O)C2=C3O