Corylifol A

一种黄酮类化合物；抑制CES2活性(Ki=0.62µM)并在使用HeLa细胞的报告试验中诱导ERα和ERβ转录激活（0.1-10µM）；对Hep3B肝细胞癌细胞有细胞毒性（IC50=13.5µg/ml），并抑制IL-6诱导的STAT3启动子活性（报告试验中的IC50=0.81µM）。A flavonoid; inhibits CES2 activity (Ki = 0.62 µM) and induces ERα and ERβ transcriptional activation in reporter assays using HeLa cells from 0.1-10 µM; is cytotoxic to (IC50 = 13.5 µg/ml), and inhibits IL-6-induced STAT3 promoter activity in (IC50 = 0.81 µM in a reporter assay), Hep3B hepatocellular carcinoma cells.分子式C25H26O4分子量390.5O=C1C(C2=CC(C/C=C(C)/CC/C=C(C)\C)=C(C=C2)O)=COC3=CC(O)=CC=C31