Apiin

一种具有多种生物活性的黄酮类糖苷；在使用人类酶的无细胞测定中抑制Aurora B激酶（IC50=12.14µM）；在10和50µg/ml时抑制LPS诱导的J774.A1巨噬细胞中NO释放和iNOS水平的增加；清除DPPH、超氧化物和羟基自由基（IC50分别为68、390和48µg/ml）；在50mg/kg时增加小鼠血清、脑、心脏、肝脏和肾脏中的SOD和过氧化氢酶水平。A flavonoid glycoside with diverse biological activities; inhibits Aurora B kinase in a cell-free assay using the human enzyme (IC50 = 12.14 µM); inhibits LPS-induced increases in NO release and iNOS levels in J774.A1 macrophages at 10 and 50 µg/ml; scavenges DPPH, superoxide, and hydroxyl radicals (IC50s = 68, 390, and 48 µg/ml, respectively); increases SOD and catalase levels in mouse serum, brain, heart, liver, and kidney at 50 mg/kg.分子式C26H28O14分子量564.5O=C1C2=C(O)C=C(O[C@H]3[C@H](O[C@@]4([H])[C@H](O)[C@](CO)(O)CO4)[C@@H](O)[C@H](O)[C@@H](CO)O3)C=C2OC(C5=CC=C(O)C=C5)=C1