Neuromedin U-23 (rat) (trifluo

肽NMUR激动剂；参与多种生物过程，包括平滑肌收缩、能量稳态和痛觉；NMUR1激动剂（使用HEK293细胞进行钙动员测定时，人类受体的EC50=0.17nM）和NMUR2激动剂（表达人类受体的CHO细胞中，花生四烯酸释放的EC50=~1.4-2nM）；在1µM浓度下诱导大鼠分离结肠平滑肌条收缩；在36µg/只动物剂量下，降低小鼠体重和食物摄入量，并升高核心体温；鞘内给药可降低大鼠冯弗雷试验中的机械痛阈值。A peptide NMUR agonist; involved in diverse biological processes, including smooth muscle contraction, energy homeostasis, and nociception; an agonist of NMUR1 (EC50 = 0.17 nM for the human receptor in a calcium mobilization assay using HEK293 cells) and NMUR2 (EC50 = ~1.4-2 nM for arachidonic acid release in CHO cells expressing the human receptor); induces contractions in isolated rat colon smooth muscle strips at 1 µM; decreases body weight and food intake and increases core body temperature in mice at 36 µg/animal; intrathecal administration decreases the mechanical pain threshold in the von Frey test in rats.分子式C124H180N34O31 • XCF3COOH分子量2643O=C([C@H]1N(CCC1)C([C@H](C)NC([C@H](C(C)C)NC([C@H]2N(CCC2)C(CNC([C@H](CCC(N)=O)NC([C@@H](NC([C@H](CCC(O)=O)NC([C@H](CC(N)=O)NC([C@H](C(C)C)NC([C@H](CCCCN)NC([C@@H](N)CC3=CC=C(C=C3)O)=O)=O)=O)=O)=O)CC4=CC=C(C=C4)O)=O)=O)=O)=O)=O)=O)N[C@@H](CO)C(NCC(NCC(N[C@@H](CC5=CC=CC=C5)C(N[C@@H](CC6=CC=CC=C6)C(N[C@@H](CC(C)C)C(N[C@@H](CC7=CC=CC=C7)C(N[C@@H](CCCNC(N)=N)C(N8[C@@H](CCC8)C(N[C@@H](CCCNC(N)=N)C(N[C@H](C(N)=O)CC(N)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O.OC(C(F)(F)F)=O