SRT 3025 (hydrochloride)

SIRT1激活剂；2µM浓度下可增加小鼠BMDM中的SIRT1水平并抑制RANKL诱导的破骨细胞生成；抑制SU.86.86细胞增殖(IC50=0.98µM)；降低以3.18g/kg高胆固醇饮食喂养的ApoE-/-小鼠的血浆LDL、VLDL和总胆固醇水平。A SIRT1 activator; increases SIRT1 levels in, and inhibits RANKL-induced osteoclastogenesis of, mouse BMDMs at 2 µM; inhibits proliferation of SU.86.86 cells (IC50 = 0.98 µM); decreases plasma levels of LDL, VLDL, and total cholesterol in ApoE-/- mice fed a high-cholesterol diet at 3.18 g/kg.分子式C31H31N5O2S2 • HCl分子量606.2O=C(C1=C(CCCOC)SC(C2=CC=CC=C2)=N1)NC3=C(C4=NC5=CC(CN6CCCC6)=CN=C5S4)C=CC=C3.Cl