Adenylosuccinic Acid (ammonium

嘌呤核苷酸和嘌呤核苷酸循环中的中间体；在细胞质中通过ADSL转化为AMP和富马酸；在膜片钳测定中，10µM可抑制大鼠棕色脂肪细胞分离中钙诱导的非选择性阳离子通道激活；在100µM时可诱导豚鼠子宫分离条收缩；在10µM时可增加INS-1832/13胰岛素瘤细胞中葡萄糖诱导的胰岛素胞吐；减少缺乏肌营养不良蛋白的DMDmdx小鼠模型中的肌肉损伤和假性肥大。A purine nucleotide and an intermediate in the purine nucleotide cycle; converted into AMP and fumarate by ADSL in the cytosol; inhibits calcium-induced activation of non-selective cation channels in isolated rat brown adipocytes in a patch-clamp assay at 10 µM; induces contractions in isolated guinea pig uterus strips at 100 µM; increases glucose-induced insulin exocytosis in INS-1 832/13 insulinoma cells at 10 µM; decreases muscle damage and pseudohypertrophy in a dystrophin-deficient mdx mouse model of DMD.分子式C14H14N5O11P • 4NH4分子量531.4[O-]P(OC[C@H]([C@@H](O)[C@H]1O)O[C@@]1([H])N2C=NC3=C(N[C@@H](CC([O-])=O)C([O-])=O)N=CN=C32)([O-])=O.[NH4+].[NH4+].[NH4+].[NH4+]