Ganodermanontriol

一种三萜；抑制HIV-1蛋白酶活性(IC50=70µM)，并在667µM时将5α-还原酶活性降低32%；在25和50µM时抑制MDA-MB-231人乳腺癌细胞的增殖、菌落形成、侵袭和迁移；在5mg/kg时减少肝细胞坏死，并增加LPS/D-半乳糖胺诱发的急性肝损伤小鼠模型中的肝脏TNF-α和IL-6水平。A triterpene; inhibits the activity of HIV-1 protease (IC50 = 70 µM), as well as reduces 5α-reductase activity by 32% at 667 µM; inhibits proliferation, colony formation, invasion, and migration of MDA-MB-231 human breast cancer cells at 25 and 50 µM; reduces hepatocyte necrosis and increases in hepatic TNF-α and IL-6 levels in a mouse model of LPS/D-galactosamine-induced acute liver injury at 5 mg/kg.分子式C30H48O4分子量472.7C[C@@]12C3=CC[C@](C)([C@]([C@@H](CC[C@H](O)[C@@](O)(C)CO)C)([H])CC4)[C@]4(C)C3=CC[C@@]1([H])C(C)(C(CC2)=O)C