3,8'-Biapigenin

一种具有多种生物活性的双黄酮类化合物；抑制PTP1B（IC50=4.5µM）并在5和10µM时刺激3T3-L1细胞的葡萄糖摄取；抑制CYP3A4、CYP2C9和CYP1A2（Kis分别为0.038、0.32和0.95µM）；在10µM时逆转大鼠胚胎海马神经元中由海因酸和NMDA诱导的细胞死亡；在8mg/kg时减少角叉菜胶诱导的爪水肿并防止大鼠吲哚美辛诱导的胃病变。A biflavonoid with diverse biological activities; inhibits PTP1B (IC50 = 4.5 µM) and stimulates glucose uptake in 3T3-L1 cells at 5 and 10 µM; inhibits CYP3A4, CYP2C9, and CYP1A2 (Kis = 0.038, 0.32, and 0.95 µM, respectively); reverses kainiate and NMDA-induced cell death in isolated rat embryonic hippocampal neurons at 10 µM; decreases carrageenan-induced paw edema and protects against indomethacin-induced gastric lesions in rats at 8 mg/kg.分子式C30H18O10分子量538.5O=C1C=C(C2=CC=C(O)C=C2)OC3=C1C(O)=CC(O)=C3C4=C(C5=CC=C(O)C=C5)OC6=C(C(O)=CC(O)=C6)C4=O