Diflucortolone 21-valerate

一种糖皮质激素；局部使用时，对由巴豆油诱发的耳部水肿的大鼠模型具有抗炎作用（ED50=9.7µg/ml）；在无毛犬中，以0.1%的浓度长期局部使用时，会引起皮肤炎症并使表皮变薄；在致敏之前和之后局部使用时，会增加特应性皮炎小鼠模型中的过敏性和非过敏性皮肤炎症。A glucocorticoid; has anti-inflammatory effects in a rat model of croton oil-induced ear edema when applied topically (ED50 = 9.7 µg/ml); induces skin inflammation and thins the epidermis in hairless dogs following chronic topical administration at 0.1%; increases allergic- and non-allergic-mediated skin inflammation in mouse models of atopic dermatitis when applied topically prior to and following sensitization.分子式C27H36F2O5分子量478.6F[C@@]12[C@](C[C@@H](C([C@@]2(C=C3)C)=CC3=O)F)([H])[C@@]4([H])[C@](C[C@@H]1O)([C@H]([C@@H](C4)C)C(COC(CCCC)=O)=O)C