Efonidipine

L型和T型钙通道抑制剂；抑制仓鼠Cav1.2a和人类Cav3.2（IC50分别为1.8和350nM）；抑制小鼠分离心肌细胞中的L型和T型钙通道和胎牛血清诱导的肥大；以200mg/kg的剂量增加由结扎左冠状动脉引起的急性心肌梗死小鼠模型的存活率；抑制SARS-CoV-2 Mpro（IC50=38.5µM）。An L- and T-type calcium channel inhibitor; inhibits hamster Cav1.2a and human Cav3.2 (IC50s = 1.8 and 350 nM, respectively); inhibits L- and T-type calcium channels and fetal bovine serum-induced hypertrophy in isolated mouse cardiomyocytes; increases survival in a mouse model of acute myocardial infarction induced by ligation of the left coronary artery at 200 mg/kg; inhibits SARS-CoV-2 Mpro (IC50 = 38.5 µM).分子式C34H38N3O7P分子量631.7O=C(C1=C(C)NC(C)=C(P2(OCC(C)(CO2)C)=O)C1C3=CC([N+]([O-])=O)=CC=C3)OCCN(CC4=CC=CC=C4)C5=CC=CC=C5