A-867744

α7nAChRs的正向变构调节剂；对α7nAChRs具有选择性，而对含有α3β2和α4β2亚基的nAChRs（IC50s分别为0.023、19.5和6.4µM）和5-HT3A受体（Ki=>30µM）具有选择性；增强表达人类α7nAChRs的非洲爪蟾卵母细胞中的ACh诱导电流（EC50=~1µM）；在0.1-10μmol/kg、ip剂量下，改善小鼠成对听觉刺激范式中的感觉门控缺陷。A positive allosteric modulator of α7 nAChRs; selective for α7 nAChRs over α3β2- and α4β2 subunit-containing nAChRs (IC50s = 0.023, 19.5 and 6.4 µM, respectively) and 5-HT3A receptors (Ki = >30 µM); potentiates ACh-induced currents in Xenopus oocytes expressing human α7 nAChRs (EC50 = ~1 µM); improves sensory gating deficits in a paired auditory stimulus paradigm in mice from 0.1-10 μmol/kg, i.p.分子式C20H19ClN2O3S分子量402.9CC1=C(C(CC)=O)C=C(C2=CC=C(Cl)C=C2)N1C3=CC=C(S(N)(=O)=O)C=C3