ZM 449829

JAK3抑制剂(IC50=0.158µM)和ZM329923降解产物；对JAK3的选择性优于EGFR和JAK1（IC50s分别为10和19.95µM），但会抑制TGM2和FXIIIa（IC50s分别为0.005和0.006µM）；降低MCF-7衍生乳球内CSC的形成；10µM时降低MCF-7细胞的迁移和菌落形成；10µM时抑制C.burnetii感染的HeLa和THP-1细胞中复制空泡的形成。An inhibitor of JAK3 (IC50 = 0.158 µM) and a degradation product of ZM 329923; selective for JAK3 over EGFR and JAK1 (IC50s = 10 and 19.95 µM, respectively) but does inhibit TGM2 and FXIIIa (IC50s = 0.005 and 0.006 µM, respectively); decreases the formation of CSC within MCF-7-derived mammospheres; decreases migration of, and colony formation by, MCF-7 cells at 10 µM; inhibits formation of replication vacuoles in C. burnetii-infected HeLa and THP-1 cells at 10 µM.分子式C13H10O分子量182.2O=C(C1=CC2=C(C=CC=C2)C=C1)C=C